Craniocervical Instability (CCI): Understanding, Diagnosing and Treating

What is CCI?

Craniocervical Instability (CCI) is a condition where the ligaments supporting the connection between the skull and upper cervical spine become lax or damaged. This instability can lead to excessive movement between the head and neck, often causing significant symptoms due to pressure on nerves and blood vessels in this delicate area.

Potential Causes of CCI

CCI can result from a variety of factors, including:

  • Trauma or Injury: Car accidents, falls, and other head or neck injuries can damage the ligaments that support the craniocervical junction.
  • Genetic Conditions: Disorders such as Ehlers-Danlos Syndrome or other connective tissue disorders make ligaments more susceptible to laxity.
  • Degenerative Changes: Age-related wear and tear can weaken ligaments over time, contributing to instability in the cervical spine.
  • Repetitive Strain: Chronic use of computers, cell phones, or other activities that require prolonged forward head positioning can gradually stretch the ligaments in the neck, leading to laxity and instability.

Signs and Symptoms

Patients with CCI may experience a range of symptoms, including:

  • Chronic headaches and neck pain
  • Dizziness, imbalance, or visual disturbances
  • Brain fog, memory issues, and fatigue
  • Tingling or numbness in various parts of the body
  • Jaw pain and clicking sounds in the neck

Diagnosis of CCI

Diagnosing CCI involves a comprehensive clinical examination, detailed medical history, and often specialized imaging. Clinicians may use advanced imaging techniques, such as upright MRI or Digital Motion X-ray (DMX), to assess ligament laxity and abnormal movement patterns in the upper cervical spine.

Treatment Options

Treatment for CCI ranges from conservative approaches like physical therapy and bracing to regenerative interventions. Two leading regenerative treatment options are:

  • AltPoint PNE (Percutaneous Needle Electrolysis): This innovative, minimally invasive procedure stimulates ligament healing using ultrasound-guided needling and electrical currents. AltPoint PNE requires only two treatments and offers a quicker, cost-effective alternative, with significant improvements typically seen within 4-8 weeks.
  • PICL (Percutaneous Implantation of Cellular Layers): The PICL procedure involves injecting regenerative cells directly into the damaged ligaments. While effective, it usually requires 4-6 sessions and is considerably more expensive, often totaling $40,000-$90,000.

Choosing the Right Treatment

Both AltPoint PNE and PICL aim to restore ligament stability, but the choice depends on factors like treatment goals, cost considerations, and recovery preferences. AltPoint PNE offers a streamlined, affordable approach, while PICL may be an option for more complex cases or those needing extensive cellular repair.

For more information on CCI and treatment options, please contact us.

References

  1. Centeno, C. J., et al. (2021). ‘Percutaneous Implantation of Cellular Layers (PICL) for Craniocervical Instability: Technique and Results.’ Regenexx Research Review.
  2. Hauser, R. A., et al. (2015). ‘Prolotherapy for ligament laxity and related conditions: An overview.’ Pain Physician.
  3. Henderson, F. C., et al. (2010). ‘Cranio-cervical instability in connective tissue disorders.’ Journal of Neurosurgery.
  4. Glazov, G., et al. (2014). ‘Low-level laser therapy for chronic neck pain: A meta-analysis of randomized controlled trials.’ Arthritis Research & Therapy.
  5. Day, A. L., et al. (2018). ‘Ehlers-Danlos syndrome and cervical spine instability.’ Spine Journal.
  6. Bjordal, J. M., et al. (2006). ‘Low-level laser therapy in tendinopathy.’ BMC Musculoskeletal Disorders.
  7. Wainner, R. S., et al. (2003). ‘Reliability and diagnostic accuracy of clinical special tests for craniocervical instability.’ Manual Therapy.
  8. Hamblin, M. R., et al. (2006). ‘Mechanisms of low-level light therapy.’ Proceedings of SPIE.
  9. Estévez-Rodríguez, A., et al. (2020). ‘Ultrasound-guided percutaneous needle electrolysis: A pilot study.’ Orthopaedic Journal of Sports Medicine.
  10. Chow, R. T., et al. (2009). ‘Efficacy of low-level laser therapy in neck pain management: A systematic review.’ Photomedicine and Laser Surgery.
  11. Martinez, M. C., et al. (2017). ‘Regenerative therapy for cervical spine instability.’ Journal of Regenerative Medicine.
  12. Dragoo, J. L., et al. (2011). ‘Regenerative medicine in sports-related injuries.’ Clinics in Sports Medicine.
  13. Paolillo, F. R., et al. (2011). ‘Low-level laser therapy in exercise-induced skeletal muscle fatigue.’ Journal of Photochemistry and Photobiology B.
  14. Cassano, N., et al. (2017). ‘Phototherapy and connective tissue disorders.’ Journal of Dermatology.
  15. López, C., et al. (2020). ‘Ultrasound-guided interventions in musculoskeletal injuries.’ Journal of Sports Medicine.
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